There are lots of different routes you can take, one way charters are often possible so don't forget to ask if you fancy that as an alternative. Croatia is now well set-up for charter guests with many professional marinas and harbours available for mooring.
The close proximity of the islands allows you to take spontaneous decisions about how far to go each day, with so much heritage crammed in to such a small place you will be awed by the wonders of Croatia at each new destination.